MALT-type marginal zone lymphomas are B-cell neoplasms that include extra-nodal tissues and exhibit a slow clinical course. The stomach is the predominant area, and most people are afflicted with Helicobacter pylori. Recently, there has been an increase in the bacterium’s resistance to several antibiotics, necessitating a change of treatment protocols. In regions where clarithromycin resistance surpasses 15%, it is necessary to discontinue the traditional triple therapy, and new therapies called quadruple regimens, including or excluding bismuth, are now suggested. Consequently, persons diagnosed with stomach MALT lymphoma linked with H. pylori must adhere to these revised eradication treatment protocols.