Understanding of the gut-microbiota-liver axis is still rudimentary. Over the past year, substantial progress has been made in understanding the complexity of host/microbial interactions in the context of liver disease. In this review, we provide an overview of studies which focus on liver and microbiota published between April 2018 and March 2019. The review includes novel insight in the role of microbiota in obesity, non-alcoholic fatty liver disease, autoimmune liver diseases, and liver cirrhosis. We summarize the impact on hepatocellular carcinogenesis and the influence of various microbiota factors in relation to liver disease and liver function. Finally, we included the new data on fecal microbiota transplantation (FMT) in liver disease.