Eosinophilic colitis (EoC) is a rare gastrointestinal (GI) disease that is not fully understood. It presents with different manifestations depending on the stratum and gastrointestinal area affected. EoC is characterized by intestinal inflammation rich in eosinophils, without any known causes of eosinophilia. Colon biopsies are required to identify this condition. It is not entirely clear whether EoC is a colonic manifestation of inflammatory bowel disease (IBD). To date, treatment has been based on steroids for an indefinite duration, dietary modification, and in some cases sodium cromoglycate and leukotriene receptor antagonists. We report the case of a 57 years old male patient who was admitted to the emergency department with persistent chronic diarrhea, abdominal pain, and malabsorption. After unsuccessful therapy with steroids and mesalazine, he received Lactobacillus Paracasei subsp. paracasei F19, which improved symptoms, endoscopic pattern, laboratoristic parameters and general condition.