Acne is a pathology that affects a large number of people of all ethnicities, becoming one of the main causes of visits to the dermatologist. The pathophysiology of acne is multifactorial and is still not fully understood, however, it is known that Cutibacterium acnes plays an important role in its development. The traditional approach in its management has consisted in the use of antibiotics, retinoids and topical treatments that aim to eliminate C. acnes, but these treatments collaterally damage other bacteria present in the skin microbiota that help us maintain homeostasis and protect from opportunistic pathogens. This article aims to show the impact of the skin microbiota on the development of acne.